What does TTF-1 negative mean?

What does TTF-1 negative mean?

Background: Patients with thyroid transcription factor 1 (TTF1) negative lung adenocarcinoma (ADC) have been reported to have a worse prognosis and to lack epidermal growth factor receptor (EGFR) mutations. This study describes a series of sample tumors from patients with clinically confirmed lung cancer.

Is TTF-1 positive good or bad?

In this study, we demonstrated that TTF-1 expression was a good prognostic indicator for OS and PFS in patients with stage IV lung adenocarcinoma regardless of the presence or absence of EGFR mutations. We also confirmed that TTF-1 positivity was strongly correlated with EGFR mutations.

What does P63 positive mean?

P63: scored positive when high intensity staining was present on ≥50% of tumor cells; the remainder was scored negative [10]. TTF-1: scored positive when staining was present on ≥5% of tumor cells; the remainder was scored negative [11].

What does p63 negative mean?

p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63.

What is CK7 and ttf1?

Thyroid transcription factor-1 (TTF-1), and cytokeratin 7 (CK7) and cytokeratin 20 (CK20) have recently been reported to be useful to distinguish between primary and metastatic lung adenocarcinoma.

Is p63 negative good or bad?

In the present study, p63 was found highly positive in all (100%) of the 12 squamous carcinoma in situ lesions. An assessment of the 6 atypical adenomatous hyperplasia areas that were encountered in the study showed that there was mild staining in only 1 case (16.7%) and no staining in the other 5 cases (83.3%).

Are tumors immunopositive for TTF-1 and p63?

Tumors were considered to be immunopositive for TTF-1 or p63 if the tumor cells demonstrated unequivocal nuclear staining. The extensiveness of immunoreactivity was measured as a percentage of tumor cells stained. Staining intensity was graded as absent (−), weak (1+), moderate (2+), or strong (3+).

Which poorly differentiated pulmonary squamous cell carcinomas express p63 and TTF-1?

Conversely, all (13/13) poorly differentiated pulmonary squamous cell carcinomas expressed p63 and did not express TTF-1. Immunoreactivity for p63 was also noted in bronchial reserve cells and metaplastic squamous cells.

Does p63 show up on immunostaining?

Immunoreactivity for p63 was also noted in bronchial reserve cells and metaplastic squamous cells. The immunostaining results obtained from the cytology slides were concordant with those of the histology or cell block sections in all cases.

Is thyroid transcription factor 1 a marker for lung cancer?

Thyroid transcription factor-1 (TTF-1) is a 38-kDa member of the NKx2 family of homeodomain transcription factors. 1 Numerous studies have shown it to be a sensitive marker for certain types of lung carcinoma including small-cell lung carcinoma, and to be nonimmunoreactive in pulmonary squamous cell carcinoma.